TASQUINIMOD SUPPRESSES TUMOR CELL GROWTH AND BONE RESORPTION BY TARGETING IMMUNOSUPPRESSIVE MYELOID CELLS AND INHIBITING C-MYC EXPRESSION IN MULTIPLE MYELOMA

Background Immunotherapy emerged as a promising treatment option for multiple myeloma (MM) patients.However, therapeutic efficacy can be hampered by the presence of an immunosuppressive bone marrow microenvironment including myeloid cells.S100A9 was previously identified as a key regulator of myeloid cell accumulation and suppressive activity.Tasqu

Software quality in use (QinU) relates to human-software interactions when a software product is used in a particular context.Currently, QinU measurement models are bound to ineffective measurement formulation and many models are subjectively incoherent.This paper proposes a novel QinU framework (QinUF) to measure QinU competently consuming softwar

Abstract Background The gut is the major organ for nutrient absorption and immune response in the body of animals.Although effects of fasting on the gut functions have been extensively studied in model animals (e.g.mice), little is known about the response of the gut to fasting in a natural condition (e.g.hibernation).During hibernation, animals en

Aedes albopictus is an invasive mosquito species that can maintain and transmit several arboviruses causing disease in humans.Understanding the determinants of its ecology and population dynamics to predict its abundance was the main objective mel axolotl of this study.Adult mosquitoes were captured weekly between 2009 and 2016 with BG sentinel tra

This research aims to formulate the similarities and the differences of the death motif employed in Ragnarok and the Book of Revelation.Both of these stories use the same motif of death but with different portrayal and explanation of the death.The data used vibrating table for chocolate in this research are Ragnarok in the epic poem Voluspa and the